Author/Editor		Bajec, Petra
Title		Bronhialna predodzivnost pri otrocih z astmo po ukinitvi zdravljenja z inhalacijskim glukokorikosteroidom
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		2002
Volume		str. 31
Language		slo
Abstract		Backgrounds. Bronchial hyperresponsiveness is the main characteristics of asthmatic airway inflammation. We can evaluate it with methacholine provocative test. Symptoms of asthma often disappear at puberty. That is why the antiinflammatory teraphy with inhalatory corticosteroids is usually stopped. 30-80% of these children develop asthma again in later life. The aim of this study was to evaluate the bronhial hyperresponsiveness in asymptomatic asthmatic children without inflammatory therapy. Methods. The study was retrospective. It included 61 children, aged 6 to 18 years, who performed methacholine test in 11 month time. Their diagnosis of asthma was allready comfired and children were asymptomatic. We divided them into two groups. The first group was the one receiving long-term therapy with a low-dose inhaled corticosteroid. The second group had no therapy for at least 3 months. We divided the second group into two subgroups (n=10). In the subgroup A there were children with positive methacholine test and in the subgroup B those with negative. We compared A and B estimating characteristics: sex, age, the dose of drug before stopping therapy, the duration of taking therapy, the duration after breaking the therapy, skin test, family history, the number of hospitalisations and the number of worsening the clinical picture of asthma in a one year time. Results. 78,7% of study subjects had positive methacholine test and 62,3% were treated without ceasing their therapy. 16,4% of subjects, who were at least 3 months without antiinflammatory therapy, had positive test and 21,3% were negative. Comparing the groups A and B using Wilcoxon's test we found statisticaly significant difference only in two parameters: the drug dose and the number of hospitalisations. (Abstract truncated at 2000 characters).
Descriptors		ASTHMA GLUCOCORTICOIDS ADMINISTRATION, INHALATION BRONCHIAL HYPERREACTIVITY METHACHOLINE CHLORIDE RETROSPECTIVE STUDIES CHILD