Author/Editor | Dželalija, Boris; Petrovec, Miro; Avšič-Županc, Tatjana; Strugar, Jadranka; Anić-Milić, Tatjana | |
Title | Randomized trial of azithromycin in the prophylaxis of Mediterranean spotted fever | |
Type | članek | |
Source | Acta Med Croatica | |
Vol. and No. | Letnik 56 | |
Publication year | 2002 | |
Volume | str. 45-7 | |
Language | eng | |
Abstract | A randomized clinical trial was undertaken to compare clinical and serologic parameters of the efficacy of one-dose azithromycin in the prophylaxis of Mediterranean spotted fever (MSF) in 122 persons with a tick bite history. Antibodies to Rickettsia conorii (R. conorir) were detected by indirect immunofluorescence (IFA) assay in 55 (45.1%) of 122 subjects. Positive result was obtained in 19 (31.1%) of 61 subjects with azithromycin prophylaxis and in 36 (59.0%) of 61 subjects without prophylaxis. Clinical signs and symptoms of MSF were recorded in 6 (9.8%) and asymptomatic infection in 30 (49.2%) of 61 subjects without prophylaxis. In subjects with prophylaxis, clinical signs of the disease were not recorded at all, whereas asymptomatic infection was detected in 19 (31.1%) of 61 subjects. Based on the resutts obtained in our study, we assume that a single dose of azithromycin is promising in MSF prevention. | |
Descriptors | BOUTONNEUSE FEVER AZITHROMYCIN RICKETTSIA FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT ANTIBODIES, BACTERIAL RANDOMIZED CONTROLLED TRIALS |