Author/Editor		Krnjak, Ljuba; Trunk, Primož; Geršak, Borut; Osredkar, Joško
Title		Biokemični in klinični pomen koncentracije proteina S100B pri bolnikih, operiranih na srcu
Translated title		Biochemical and clinical significance of protein S100B concentration at patients undergoing coronary artery bypass grafting
Type		članek
Source		Farm Vestn
Vol. and No.		Letnik 53, št. 4
Publication year		2002
Volume		str. 383-7
Language		slo
Abstract		Protein 5100 is composed from 91 aminoacids and has two specific sites for binding calcium ions. In humans protein S 100 has been found in different tissues at different concentrations. Protein S 100B belongs to the family of S 100 proteins, which contain one or more so called EF-hand motifs. All these proteins can bind calcium ions and that induce conformational change. Because of that express different biological functions. From the damage tissue S100B can be released in the circulation. Brain insult is one of major complication after operation of coronary artery bypass grafting. Cerebral injury is one of the serious complication, which appears at the coronary artery bypass grafting with cardiopulmonary bypass. The protein S 100B might be a reliable biochemical marker of cerebral injury, disease of cerebral nerves system, early detection metastases of melanomas and other cerebral complications after the head injury.
Summary		Protein S 100B je sestavljen iz 91 aminokislin in ima dve specifični mesti za vezavo kalcija. V organizmu se nahaja v različnih tkivih v različnih koncentracijah. Sodi v skupino 5100 proteinov, ti pa v EF-hand proteine. Skupna lastnost vseh teh proteinov je vezava kalcija in sprememba terciarne strukture, pri čemer proteini izražajo različne biološke funkcije. S 100B se iz poškodovanega tkiva sprošča v krvi obtok. Možganski infarkt je eden izmed glavnih pooperativnih zapletov operacij kirurške revaskularizacije miokarda s premostitveno operacijo. Poškodba možganov je eden resnejših zapletov, ki se pojavljajo pri srčnih operacijah, narejenih z uporabo zunajtelesnega krvnega obtoka. Obetaven biokemični označevalec tovrstnih možganskih poškodb je protein S 100B, ki se je že izkazal kot diagnostično pomemben pri boleznih centralnega živčnega sistema, pri zgodnjem odkrivanju metastaz melanoma in v primeru možganskih zapletov pri poškodbi glave.
Descriptors		CORONARY ARTERY BYPASS CARDIOPULMONARY BYPASS PROTEIN S POSTOPERATIVE COMPLICATIONS CEREBROVASCULAR DISORDERS PEPTIDE ELONGATION FACTORS