Author/Editor     Skalerič, Eva
Title     Raven nekaterih kazalcev vnetja in inflamatornih citokinov v serumu pacientov s parodontalno boleznijo
Type     monografija
Place     Ljubljana
Publisher     Medicinska fakulteta
Publication year     2002
Volume     str. 35
Language     slo
Abstract     1. BACKGROUND: Periodontal disease is the most widely spread disease among all chronical inflammatory diseases. The major cause of this disease are microorganisms in dental plaque. The initiation and development of inflammation in periodontal tissue is influenced by the number and type of microorganisms and by inflammatory immune host response. Analytical epidemiology and molecular biology studies in the last decade have shown that periodontal inflammation doesn't only present a risk for tooth loss but may also play a role in the development of seme systemic diseases. Periodontal disease plays a role in development of some diseases by direct flow of microorganisms into the bloodstream through ulcerated inner gingival epithelium and by increase of some inflammatory mediators and cytokines in the blood serum. 2. AIM: The aim of our study was to find out the level of inflammatory mediators(CRP, fibrinogen, procalcitonin) and inflammatory citokynes (IL-2,sII,-2R, IL-6, IL-8, TNF-alpha) in the serum of systemically healthy blood donors with periodontal disease. 3. HYPOTHESIS: Our hypothesis was that the size of soft wall of periodontal pockets in contact with bacteria (infected periodontal wound) influences the level of inflammatory mediators and cytokines in the serum . 4. METHODS: For the evaluation of infected periodontal wound we measured the circumference of the tooth neck at the cemento-enamel junction on 515 extracted teeth. We multiplied the average values of circumferences of tooth necks of individual tooth by the average value of six measurements of probing depth of individual tooth in 31 blood donors. The surn of multiplications of iadividual teeth presented the size of infected periodontal wound in an individual. The sum of multiplications of measurments of periodontal pockets which were bleeding on probing, presented the size of active infected periodontal wound. (Abstract truncated at 2000 characters).
Descriptors     PERIODONTAL DISEASES
GINGIVAL POCKET
FIBRINOGEN
CALCITONIN
C-REACTIVE PROTEIN
BLOOD DONORS
INTERLEUKIN-2
INTERLEUKIN-6
INTERLEUKIN-8
TUMOR NECROSIS FACTOR