Author/Editor		Knafelj, Rihard; Perić, Barbara
Title		Lajšanje bolečine po operaciji rame: primerjava učinkovitosti analgezije po vbrizganju ropivakaina in mešanice ropivakaina s klonidinom prek katetra v rani
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		2002
Volume		str. 30
Language		slo
Abstract		Background: Major shoulder surgery is often associated with severe postoperative pain especially within the first forty-eight hours. The efficient treatment of early postoperative pain significally reduces the occurrence of chronic pain. Pain can be treated in various ways. Recent method which enables local anesthetic administration via a catheter placed in the surgical wound treats pain effectively and with little side-effects. It is safer for the patient compared to pain treatment with systemic opioids. In order to reduce local anesthetic consumption, different pharmacological agents can be added. Sinergistic effect of small doses of clonidine, added to local anesthetic solution was shown in some studies, while the data concerning the use of clonidine in wound infiltration analgesia are lacking. Aim: The study tried to determine whether clonidine added to ropivacaine enhances ropivacaine's analgesic action compared to ropivacaine alone when given via catheter placed in the operating wound. Hypothesis: 1) pain is treated more efficiently if analgesic mixture containing clonidine is used compared to one with ropivacaine only, 2) when using the mixture of ropivacaine and clonidine the analgesic effects last longer in comparison to the use of ropivacaine alone, 3) patients treated with analgesic mixture of ropivacaine and clonidine have lesser need for additional intravenous narcotics, compared to patients receiving ropivacaine only. Methods: Patients were enrolled in the prospective, double-blind, randomized study. At the end of a surgery, a catheter was placed in the operating wound and connected to a PCA pump. Postoperatively patients in the control group self-administered 10 ml 0.55 % ropivacaine in the surgical wound with 120 min lockout interval and patients in the clonidine group 10 ml of mixture of clonidine (18,75 pg) and 0.55 % ropivacaine. (Abstract truncated at 2000 characters).
Descriptors		PAIN, POSTOPERATIVE SHOULDER JOINT INTRAOPERATIVE PERIOD CATHETERIZATION CLONIDINE ANALGESIA, PATIENT-CONTROLLED ANESTHETICS, LOCAL MORPHINE PAIN MEASUREMENT RANDOMIZED CONTROLLED TRIALS