| Author/Editor | Fister, Petja | |
| Title | Zapleti v nosečnosti pri preiskovankah z lažno pozitivnim rezultatom trojnega presejalnega testa | |
| Type | monografija | |
| Place | Ljubljana | |
| Publisher | Medicinska fakulteta | |
| Publication year | 2002 | |
| Volume | str. 38 | |
| Language | slo | |
| Abstract | BACKGROUND. Screening tests are a constituent part of efficient health care of pregnant women. With screening tests we look for pregnant women with increased risk of diseases and complications in course and outcome of pregnancy, and fetuses and children with congenital abnormalities. An important group of screening tests are tests for detecting fetal chromosomal abnormalities. The most common chromosomal abnormality in newborns is trisomy of 21. chromosome or Down's syndrome (DS). Triple hormone (screening) test (THT) is a prenatal screening test for identifying the risk of birth for a child with DS, according to log multiple of the median (MoM) of three maternal serum markers. The three hormone markers are alpha-fetoprotein (AFP), human horionic gonadotropin (hCG) and unconjugated oestriol (uE3). Beside concentrations of listed markers maternal age and fetal size are also considered. THT is performed in second trimester of pregnancy. We offer a diagnostic test to pregnant woman with positive result of THT. Pregnant women with normal karyotype results of cytogenetic diagnostics of fetal cells are classified as false positive (FP). AIM. Contradictory data are reported in literature on increased frequency of complications in pregnancy in women with FP result of THT. The aim of our retrospective research was to gather and evaluate data on course and complications in pregnancy of women from Slovenia who had THT in the period of 1997-2000. We wanted to fmd out if women with FP result of THT more often have complications of pregnancy than women with true negative (TN) result. HYPOTHESES. I. Pregnant women with FP result of THT more often have complications in pregnancy than women with TN THT result. II. Pregnant women with FP result of THT more often deliver prematurely and have more peripartal complications than women with TN result of THT. (Abstract truncated at 2000 characters). | |
| Descriptors | DOWN SYNDROME PRENATAL DIAGNOSIS ALPHA-FETOPROTEINS GONADOTROPINS, CHORIONIC ESTRIOL PREGNANCY RETROSPECTIVE STUDIES PREGNANCY COMPLICATIONS MATERNAL AGE FETAL DEVELOPMENT PREGNANCY TRIMESTER, SECOND KARYOTYPING |