Author/Editor     Frank, Mojca
Title     Ugotavljanje ogroženosti okuženih s HIV zaradi oportunističnih okužb z analizo limfocitnih populacij v krvi
Type     monografija
Place     Ljubljana
Publisher     Medicinska fakulteta
Publication year     2002
Volume     str. 83
Language     slo
Abstract     BACKGROUND. HIV induced immunodeficiency makes HIV patients highly susceptible to infection with opportunistic microbes. Immune activation induced by infection is accompanied by an increase in virus replication, followed by greater depletion of CD4 cells. An effective vaccination could therefore diminish the frequency of opportunistic infections in HIV seropositive patients, slowing the immune deteoriation and progression of their disease. Immunodeficency in patients with HIV means also smaller immune responsiveness to antigenic stimuli. Therefore, postvaccionational antibody responses in HIV seropositive are lower and it is questionable, if they are protective at all. However, with concomitant activation of CD4 cells, making them susceptible to HIV infection, immunisation interferes with pathogenetic mechanisms of HIV infection and could therefore have either positive or negative consequences in HIV patients. AIM. We wanted to find out, whether influenza vactination was effective in our patients, wheather using a combination of vaccines, meaning a stronger antigenic stimulus for depressed immune system in patients with HIV, could improve their antibody responses on vaccination, and how it could be influenced by category of HIV infection, plasma viral load and concentration of CD4 cells before vaccination. We were also interested, if there were any statistically important differences in immune status and viral load following vaccination, whether stronger immune activation with a combination of vaccines was accompanied by greater postvaccionational changes in observed parameters, and how they were influenced by basal plasma viremia, prevaccionational concentration of CD4 cells and category of HIV infection. (Abstract truncated at 2000 characters).
Descriptors     HIV INFECTIONS
OPPORTUNISTIC INFECTIONS
INFLUENZA VACCINE
ANTIBODIES, VIRAL
CD4 LYMPHOCYTE COUNT
POLYMERASE CHAIN REACTION
ENZYME-LINKED IMMUNOSORBENT ASSAY
CD4-CD8 RATIO
T-LYMPHOCYTE SUBSETS
IGG
IGA
VIREMIA
HIV-1
ANTIBODIES, MONOCLONAL
FLOW CYTOMETRY
RETROSPECTIVE STUDIES