Author/Editor		Glušič, Mojca
Title		Zgodnje odkrivanje ponovitve bolezni pri bolnikih z operabilnim rakom debelega črevesa in danke
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		2002
Volume		str. 50
Language		slo
Abstract		The incidence of colorectal cancer is increasing. It ranks first in frequency among gastrointestinal malignancies in Slovenia. After radical surgical treatment, being the most important method of treatment, 35-40% of patients will present with recurrences. 60% of patients has a stage II or III disease at the time of diagnosis. In 35-40% of them the cancer will recur. Most recurrences among patients after radical surgical treatment of colorectal cancer occur in the first three years after the surgery. If recurrences are radically resected, it results in long-term survival. Any other specific oncologic treatment-chemotherapy and/or radiation in case of recurrence only means palliation. It is important that recurrences in liver and metachronous colorectal cancer are detected at an aerly stage, while still being curable. The follow up around the world and in our country comprises many investigations. The aim of our study was to establish the most sensible and efficient way of follow up, focused on the detection of curable tumor recurrences at an early stage. We wanted to evaluate the value of abdominal ultrasound, CEA and clinical examination as methods of follow up. In our investigation we looked over the medical charts of 174 patients who had been operated on for histologically confirmed colon cancer stage III or rectal cancer stage II or III. After the surgery they received the standard chemotherapy, patients with rectal cancer received radiation therapy as well. All the patients were subjected to regular post-operative follow up, which comprised clinical and laboratory examinations, determination of serum CEA levels, colonoscopy, abdominal ultrasound and X-ray of the lung. Out of the total 174 patients, 113 had been operated on for colon cancer, and 61 for rectal cancer. The median duration of follow up was 6,3 years. Within the observation period, recurrence was detected in 57 (30%) of patients. (Abstract truncated at 2000 characters).
Descriptors		COLORECTAL NEOPLASMS NEOPLASM RECURRENCE, LOCAL NEOPLASM STAGING NEOPLASM METASTASIS ABDOMEN COLPOSCOPY CARCINOEMBRYONIC ANTIGEN SURVIVAL ANALYSIS FOLLOW-UP STUDIES