Author/Editor		Marin, Jožica
Title		Človeški herpesvirus 6
Translated title		Human herpesvirus 6
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 72, št. 2
Publication year		2003
Volume		str. 91-5
Language		slo
Abstract		Background. Human herpesvirus 6 belongs to betaherpesviruses. This is a lymphotropic virus which is widely spread in a population. The most frequent way of virus transmission is by saliva. For this reason the first contact usally occurs early in a childhood period. Clinical manifestation might be expressed as exanthem subitum or roseola infantum. In adults primary infections are a rare event while virus reactivation might be very frequent. Conclusions. Human herpesvirus 6 is believed to be the most neurotropic among all herpesviruses. It even can cause central nervous system disease in an immunocompetent person. The most important role of human herpesvirus 6 is in provoking complications in HIV-infected individuals and in patients after organ transplantations, as it causes immunosupression even more severe. The possible connection of human herpesvirus 6 with multiple sclerosis, chronic fatigue syndrome and some neoplasmas remains to be clarified. Human herpesvirus 6 infection can be most easily diagnosed by serological methods; the virus could be detected by monoclonal antibodies and by the use of the methods of molecular biology.
Summary		Izhodišča. Človeški herpesvirus 6 spada med betaherpesviruse. Je limfotropni virus, ki je zelo razširjen. Najpogostejši način prenosa je s slino. Zato do prvih stikov z virusom navadno pride že v zgodnjem otroštvu. Klinično se okužba lahko izrazi kot značilen izpuščaj - exanthem subitum ali roseola infantum. Pri odraslih so primarne okužbe redke, zelo pogosto pa se virus reaktivira. Zaključki. Človeški herpesvirus 6 lahko poškoduje osrednji živčni sistem. Celo pri imunsko normalno odzivnih posameznikih lahko povzroča meningoencefalitis in druge bolezni. Virus ima pomembno vlogo pri osebah, okuženih s HIV, in pri bolnikih po presaditvi organov. Povzroča zaplete, ker prispeva k še večji imunski pomanjkljivosti. Možnih povezav med človeškim herpesvirusom 6 in multiplo sklerozo, sindromom kronične utrujenosti in nastankom novotvorb še niso potrdili. Okužbo z virusom najlaže dokažemo s spremljanjem serološkega profila; virus lahko dokažemo tudi z monoklonskimi protitelesi in z molekularno biološkimi metodami.
Descriptors		HERPESVIRUS 6, HUMAN EXANTHEMA SUBITUM ROSEOLOVIRUS INFECTIONS