| Author/Editor | Naumovski, John; Simova, Nina; Janevik-Ivanovska, Emilija; Kovkarova, Elizabeta; Georgievska-Kuzmanovska, Sonja | |
| Title | Scintigraphic detection of peptic lesions with the method of radiolabelled sucralfate | |
| Translated title | Scintigrafsko ugotavljanje peptične razjede s sukralfatom, označenim z radioizotopom | |
| Type | članek | |
| Source | Radiol Oncol | |
| Vol. and No. | Letnik 37, št. 1 | |
| Publication year | 2003 | |
| Volume | str. 9-12 | |
| Language | eng | |
| Abstract | Background. Sucralfate is an antiulcer agent that after peroral application strongly adheres to mucosal defects and in that way provides a protective barrier to further damage from acid and pepsin. If radiolabelled with a gamma isotope, it could be detected under a gamma camera pointing lesions to which it adhered. With the aim to confirm a suitable noninvasive method for investigation of caustic lesians of the upper gastrointestinal tract we evaluated in a preliminary study the validity of the radiolabelled sucralfate scintigraphy in detection of peptic disease. Patients and methods. With that purpose, 35 patients after an endoscopic examination underwent scintigraphy with Tc-99m-DTPA sucralfate. Patients were divided in two groups: a group of 20 patients with endoscopic confirmed peptic disease and a control group of 15 persons who had not any disease of the upper gastrointestinal tract. Results. Lising the test for clinical evaluation of a new method, the scan showed sensitivity of 75%, specificity of 100% and accuracy of 85,7%. Conclusions. Scintigraphy with Tc-99m-DTPA sucralfate promoting it as an additional method, complementary to routine investigations in detecting mucosal lesions. | |
| Summary | Izhodišča. Sukralfat uporabljamo za zdravljenje ulkusne bolezni. Po peroralni aplikaciji se močno veže na poškodovano sluznico in na ta način zaščiti sluznico pred nadaljnjo poškodbo s kislino in pepsinom. Če sukralfat označimo z radioizotopom, ki je sevalec gama žarkov, lahko z gama kamero zaznamo morebitno poškodbo sluznice. Tako je bil namen študije potrditi primerno neinvazivno metodo za ugotavljanje razjede sluznice zgornjega gastrointestinalnega trakta. V preliminarni študiji smo ocenili pomen scintigrafije s sukralfatom, ki smo ga označili z radioizotopom, pri ugotavljanju peptične razjede. Bolniki in metode. Pri 35 bolnikih, ki so bili predhodno endoskopsko pregledani, smo naredili scintigrafijo s Tc-99m-DTPA sukralfatom. Bolniki so bili razdeljeni v 2 skupini: 20 jih je imelo endoskopsko potrjeno peptično razjedo, kontrolna skupina 15 bolnikov pa ni imela bolezni v zgornjem gastrointestinalnem traktu. Rezultati. Pri uporabi nove klinične metode smo ugotovili, da je imela scintigrafija 75 % senzitivnosti in 100 % specifičnosti ter 85,7% natančnosti. Zaključki. Scintigrafija s Tc-99m-DTPA sukralfatom lahko predstavlja dodatno dopolnjujočo metodo pri rutinskem ugotavljanju sluzničnih razjed. | |
| Descriptors | PEPTIC ULCER SUCRALFATE ISOTOPE LABELING ENDOSCOPY, GASTROINTESTINAL PREDICTIVE VALUE OF TESTS SENSITIVITY AND SPECIFICITY |