Author/Editor		Svetina, S; Brumen, M; Gros, M; Vrhovec, S; Žnidarčič, T
Title		On the variation of parameters that characterize the state of a physiological system. Red blood cells as an example
Type		članek
Source		Adv Comput Bioeng Ser
Vol. and No.		Letnik 7
Publication year		2003
Volume		str. 3-14
Language		eng
Abstract		Analysis of the population variation of parameters that characterize the state of a physiological system may provide a useful insight into its properties and behavior. To demonstrate this, we have analyzed the population variation in red blood cell (RBC) volume, hemoglobin content, hemoglobin concentration, density, cation content and membrane area. Because of the physical and chemical laws governing the behavior of a single cell, some of these parameters are strictly interrelated. It is shown how the corresponding causal relations give rise also to relations between the parameters of the corresponding statistical distributions, i.e. standard deviations and correlation coefficients. A classification of the cell parameters treated is suggested, in the sense that RBC membrane area and hemoglobin content, which are established in the course of the cell maturation, are hierarchically at a higher level than, for instance, the cell density which is essentially defined by the instant values of hemoglobin and water content. Existing experimental data on some statistical parameters are used to derive a complete overview of RBC variations with regard to the cell parameters considered.
Descriptors		CATIONS OSMOLAR CONCENTRATION ERYTHROCYTES ERYTHROCYTE INDICES ERYTHROCYTE MEMBRANE HEMOGLOBINS MODELS, THEORETICAL