Author/Editor		Beović, Bojana
Title		Načela antibiotičnega zdravljenja okužb na spodrnjih dihalih
Translated title		Principles of appropriate antibiotic treatment of lower respiratory tract infections
Type		članek
Source		Krka Med Farm
Vol. and No.		Letnik 24, št. 35
Publication year		2003
Volume		str. 39-48
Language		slo
Abstract		General principles o f the treatment of infections should be applied in antimicrobial treatment of patients with community-acquired lower respiratory tract infections. The chosen antibiotics should be effective, safe and well tolerated with minimal impact on antimicrobial resistance. The cost of the treatment should be reasonable. In most cases the treatment o f lower respiratory tract infections is empirical, taking into account possible etiologic agents and their susceptibility to antibiotics. Clinical significance of in vitro antimicrobial resistance in respiratory pathogens remains unclear but cases of unsuccess ful treatment remind us to stay alert. Specially designed antimicrobial treatment is needed at extremes of age and in patients with underlying diseases. The route of antibiotic administration depends upon severity of disease; seguential treatment is possible in many hospitalized patients. The duration of treatment is not defined and depends upon the causative agent and the host.
Summary		Pri izbiri antibiotika za zdravljenje zunajbolnišničnih okužb na spodnjih dihalih moramo upoštevati osnovna načela antibiotičnega zdravljenja, ki vključujejo učinkovitost zdravila, njegovo varnost, sodelovanje bolnika, vpliv na odpornost bakterij in ceno zdravljenja. Bolnikom z okužbami na spodnjih dihalih antibiotike najpogosteje predpisujemo izkustveno. Ob tem upoštevamo možne povzročitelje in njihovo odpornost proti antibiotikom. Pomen in vitro odpornosti bakterij za klinični učinek ni povsem jasen, primeri neuspešnega zdravljenja pa nas opozarjajo na previdnost. Predpisovanje antibiotiikov moramo posebej prilagoditi pri skrajnih starostnih skupinah in pri bolnikih z osnovnimi boleznimi. Način odmerjanja antibiotikov je odvisen od stopnje bolezni, možno je tudi sekvenčno zdravljenje. Trajanje zdravljenja ni strogo določeno, odvisno je od povzročitelja bolezni in zdravstvenega stanja bolnika.
Descriptors		RESPIRATORY TRACT INFECTIONS ANTIBIOTICS PNEUMONIA COMMUNITY-ACQUIRED INFECTIONS DISEASE PROGRESSION ANTIBIOTICS, LACTAM ANTIBIOTICS, MACROLIDE TETRACYCLINES QUINOLONES