Author/Editor		Breznik, M; Pečar, S
Title		Trombinski inhibitorji
Translated title		Thrombin inhibitors
Type		članek
Source		Farm Vestn
Vol. and No.		Letnik 48, št. 4
Publication year		1997
Volume		str. 545-60
Language		slo
Abstract		The blood coagulation enzyme thrombin plays a central role in thrombosis and hemostasis. A safe and effective inhibitor of thrombin could be useful in the treatment of cardiovascular problems secondary to imbalances in the equilibrium between hemostasis and fibrinolysis (myocardial infarction, venous and arterial thrombosis ...). Due to high occurrence of cardiovascular problems the development of small molecule thrombin active site inhibitors is an area of intense research. A brief review on recent progress of Ihrombin inhibitors development is presented in this article.
Summary		Trombin, ki je serinska proteaza, je eden od ključnih encimov pri procesih strjevanja krvi in razvoju tromboze. Varen in učinkovit inhibitor trombina bi bil dobro zdravilo za preprečevanje zapletov, ki se pojavijo zaradi neravnovesij med hemostazo in fibrinolizo (srčni infarkt, venska in arterijska tromboza ...). Zaradi pogostnosti kardiovaskularnih bolezni je razvoj nizkomolekularnih inhibitorjev trombina področje, ki mu farmacevtska industrija namenja veliko pozornosti. V članku predstavljamo pregled inhibitorjev trombina.
Descriptors		THROMBIN ANTICOAGULANTS HEPARIN WARFARIN HIRUDIN BLOOD COAGULATION THROMBOEMBOLISM BINDING SITES ALDEHYDES KETONES