Author/Editor		Videnšek-Podgorelec, Ana
Title		Prenosljive spongiformne encefalopatije
Translated title		Transmissible spongiform encephalopathies
Type		članek
Source		Farm Vestn
Vol. and No.		Letnik 52, št. 4
Publication year		2001
Volume		str. 283-6
Language		slo
Abstract		Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are fatal degenerative brain diseases that occur in humans and certain animal species. It has been proposed that the infectious agent of these diseases is an infectious protein which has been designated by the term »prion«. The nature of this infectious agent involved in prion diseases has still not been fully elucidated, but an abnormal isoform of prion protein (PrPs°), which is generated by the post translational modiiication of cellular protein (PrPc), has been found to accumulate in the affected brains. These agents propagate in infected individuals without induction of a detectable immune response. In the light of the available scientific knowledge appropriate mesures to minimise the risk of transmission of TSEs via medicinal products derived from animal origin have been taken.
Summary		Prenosljive spongiformne encefalopatije, poznane tudi kot prionske bolezni, so degenerativne možganske bolezni, ki se pojavljajo tako pri živalih kot pri ljudeh. Nekateri znanstveniki so mnenja, da je nalezljivi povzročitelj teh bolezni kužni protein, ki so ga poimenovali »prion«. Narava tega nalezljivega povzročitelja pri prionskih boleznih {e ni popolnoma raziskana. V okuženih možganih so našli nenormalno obliko prionskega proteina (PrPs°), ki naj bi nastal s posttranslacijsko modifikacijo celičnega proteina (PrP`). Povzročitelj prionskih bolezni se širi brez razpoznavnega imunskega odgovora. Imunski sistem verjetno pomaga, namesto da bo preprečeval širjenje prionov. Na osnovi sedaj dostopnega znanja so uvedli ukrepe za zmanjšanje tveganja prenosa povzročitelja spongiformnih encefalopatij preko zdravil, ki vsebujejo sestavine živalskega izvora, na človeka.
Descriptors		PRIONS PRION DISEASES ENCEPHALOPATHY, BOVINE SPONGIFORM CREUTZFELDT-JAKOB SYNDROME