Author/Editor     Ihan, A
Title     Imunski mehanizmi nutritivne alergije
Translated title     Immunological mechanisms of food allergy
Type     članek
Source     In: Gregorič A, editor. Nutritivna alergija. Farmakologija perinatalnega obdobja. Skrb za zdravje v prvem letu življenja. Zbornik predavanj 13. srečanje pediatrov v Mariboru z mednarodno udeležbo; 2003 apr 4-5; Maribor. Maribor: Splošna bolnišnica Maribor,
Publication year     2003
Volume     str. 13-7
Language     slo
Abstract     Food allergy is an adverse reaction to foods that is mediated immunologically. Clinical manifestations of food allergy include symptoms of the gastrointestinal, cutaneous and respiratory systems, as well as systemic anaphylaxis. Although food hypersensitivity might be divided in IgE- and non-IgE mediated food allergy, there is a large body of evidence implicating T lymphocytes overall in the pathogenesis of food allergy. Priming of naive T cells will occur mainly in Peyer's patches (PP), where surface receptors will help to initiate migration of the cells to the submucosa. Various antigen-presenting cells (e.g. dendritic cells, M cells) will present food antigen-derived epitopes and initiate either non-responsiveness, or a food-mediated immune response. The development of food - specific T helper 1 (Th1) versus Th2 cells is a major branch point in the immune response. It is an important determinant of whether the response to food will lead to tolerance or hypersensitive reactions.
Descriptors     FOOD HYPERSENSITIVITY
IMMUNITY, MUCOSAL
CYTOKINES
INFLAMMATION
T-LYMPHOCYTES, HELPER-INDUCER
IGA
ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE
INTERLEUKIN-2
TH1 CELLS
TH2 CELLS
INTERFERON TYPE II
INTERLEUKIN-12
INTERLEUKIN-4
INTERLEUKIN-10
CHEMOKINES