Author/Editor		Geršak, K
Title		Zdravila v nosečnosti in novorojenček
Translated title		Drugs in pregnancy and neonatal risk
Type		članek
Source		In: Gregorič A, editor. Nutritivna alergija. Farmakologija perinatalnega obdobja. Skrb za zdravje v prvem letu življenja. Zbornik predavanj 13. srečanje pediatrov v Mariboru z mednarodno udeležbo; 2003 apr 4-5; Maribor. Maribor: Splošna bolnišnica Maribor,
Publication year		2003
Volume		str. 72-5
Language		slo
Abstract		From 2 to 5% of babies are born with congenital malformations, which are caused by teratogens, drugs in particular, in only 2-3%. The data collected by the National Perinatal lnformational System for the period 1997-99 show that during pregnancy 83% of women are taking at least one drug. Environment may have a harmful effect on the embryo. Whenever the issuing result is a congenital physical handicap or a changed function of an organ, we speak of teratogenic effects. The effect of a harmful teratogenic activity is associated with the fetal genotype, the developmentalstage of the fetus, and characteristics, mechanism of activity and dose of the teratogen. The most severe consequences occur when the embryo is exposed to teratogenic effects, i.e. between the 3rd and 8th gestational week. These consequences lead to accelerated or irregular apoptosis, decreased biosynthesis, changed cell migration and mechanical disruption of tissues or organs. For potential teratogenic or otherwise harmful effects on the fetus, the FDA classification of drugs is used in Slovenia, the drugs being classified into more groups in the Drug Registry of the Republic of Slovenia. Treatment of the pregnant woman with drugs is justified when the risk of her health prevails over the risk of a harmful effect on the fetus. We should clearly explain this to the woman, and should motivate her appropriately. The conversation should focus on the type and incidence of the congenital malformation, resulting from a particular drug. Refusal of taking the prescribed drug mayalso threaten the pregnancy. Appropriate and data-based counselling may change a too rush decision on termination, and lead to a successful management of pregnancy.
Descriptors		DRUG THERAPY ABNORMALITIES, DRUG-INDUCED PREGNANCY THALIDOMIDE FOLIC ACID DEXAMETHASONE