Author/Editor		Felc, Z
Title		Prenos zdravil z materinim mlekom
Translated title		The transfer of medications by mother's milk
Type		članek
Source		In: Gregorič A, editor. Nutritivna alergija. Farmakologija perinatalnega obdobja. Skrb za zdravje v prvem letu življenja. Zbornik predavanj 13. srečanje pediatrov v Mariboru z mednarodno udeležbo; 2003 apr 4-5; Maribor. Maribor: Splošna bolnišnica Maribor,
Publication year		2003
Volume		str. 126-8
Language		slo
Abstract		Most medications are excreted to some extent into the mothers milk and transfered to the breast-fed infant. Physicians usually advise unnecessary interruption of breastfeeding during drug therapy of lactating women. With few exceptions (e.g., digitalis), less than 1% of the maternal dose of a medication is transferred to the breast-fed infant. Because of the large gaps between alveolar cells, medications penetrate into milk more during the neonatal period than in mature milk. The passage of maternal medications into breastfeed infants depends on a number of factors: drug factors (molecular weight, the degree of protein binding and lipid solubility, the proportion of drug that is ionised, its pH factor, its half-life, and its milk/plasma ratio), maternal factors (medication dosage and frequency and the route of administration of the drug), infant factors (age and maturity, frequency of feedings, volume of breast milk consumed, oral bioavailability, and food-drug interactions). In Lactation Risk Categories, created by male, the theoretic infant dose category is an estimate of the peak dose of medication an infant may receive during breastfeeding; the recommendations provided by the American Academy of Pediatrics are included. The lactation risk categories are the following L1"safest" drugs which have been taken bya large number of breastfeeding mothers without any adverse effects in the infants, L2"safe" drugs which have been taken by a limited number of breastfeeding mothers without any adverse effects in the infants, L3"moderately safe" there are no controlled studies in breastfeeding women, or, controlled studies show only minimal non-threatening adverse effects; (Abstract truncated at 2000 characters).
Descriptors		BREAST FEEDING DRUG THERAPY MILK, HUMAN INFANT NUTRITION INFANT