Author/Editor		Lei, Wei; de Bri, Edin
Title		The effects of load on bone and cartilage following amputation in Guinea pig osteoarthritis
Type		članek
Source		Image Anal Stereol
Vol. and No.		Letnik 20, št. Suppl 1
Publication year		2001
Volume		str. 163-8
Language		eng
Abstract		The relationship between subchondral bone and load was studied following trans-tibial amputation in Hartley guinea pigs which spontaneously develop an arthropathy in their knee joints similar to human osteoarthritis (OA). Bone, cartilage and proteoglycan changes were assessed by stereology and biochemistry. Three months after amputation, the OA changes, including volumes of cartilage, cysts and osteophytes, in addition to bone thickness, cartilage fibrillation, cartilage horizontal splitting, were all decreased. There was also an increase of bone marrow volume, accompanied by an obvious decrease in subchondral bone volume, as compared to the non-operated control group and the contralateral knee in the amputated group. In addition, the contralateral knees showed the most severe OA changes, while the control group showed more severe OA changes than the knees with the amputated legs. This is probably a result of greater load. Our findings may also suggest that progressive cartilage OA changes is associated with an increased subchondral bone volume. Moreover, these changes are probably related to axial longitudinal loading in vivo. It is also likely that amputarion has a protective effective on cartilage and bone with regards to OA development suggesting that mechanical factors are involved in OA progression.
Descriptors		OSTEOARTHRITIS KNEE JOINT AMPUTATION CARTILAGE, ARTICULAR IMAGE PROCESSING, COMPUTER-ASSISTED BONE DENSITY GUINEA PIGS