Author/Editor		Syrjaenen, Kari
Title		Methods and role of HPV detection techniques as auxiliary screening tools
Type		članek
Source		In: Eržen M, editor. Book of proceedings Training of cytotechnologists and cytopathologists in cervical cancer screening in the 21st century: new approaches to vocational training and continuing professional education; 2003 Mar 14; Ljubljana. Ljubljana: Slovenian society of gynecological oncology, colposcopy and cervical pathology,
Publication year		2003
Volume		str. 58-79
Language		eng
Abstract		In the global control of cervical cancer, a number of optional approaches are available, including measures of both primary and secondary prevention. So far, the effects of most of these measures on cervical cancer incidence and mortality have been modest. The only exception is an organised screening based on use of cervical cytology (PAP test), shown to be highly effective in reducing cervical cancer incidence and mortality in countries where implemented. Optional screening tools under vigorous testing include a) automation of cytology, and b) testing for Human papillomavirus (HPV) by different molecular tools (PCR, HCII). The efficacy of cervical cancer control critically depends on the screening programme. A plethora of different recommendations and guidelines have been elaborated by different organisations and recent consensus conferences. Their practical value remains to be established under field conditions, however. Under such circumstances, the effectiveness of e.g. HPV testing, cytology automation, and liquid-based technology, as compared with the conventional PAP test screening will be determined by a large number of factors, including a) the prevalence of HPV infections in the target population, b) accuracy of cytological diagnosis, as well as c) the costs and applicability of the HPV test and automation (or liquidbased cytology).
Descriptors		CERVIX NEOPLASMS PAPILLOMAVIRUS, HUMAN PRECANCEROUS CONDITIONS COST-BENEFIT ANALYSIS VAGINAL SMEARS POLYMERASE CHAIN REACTION