Author/Editor     Hafner, Matjaž
Title     Presaditev jeter: indikacije, priprava in vodenje po posegu
Type     članek
Source     In: Kandus A, Buturović-Ponikvar J, Bren A, editors. Transplantacija 2003. Ljubljana: Klinični oddelek za nefrologijo,
Publication year     2003
Volume     str. 334-8
Language     slo
Abstract     Liver transplantation is now widely accepted as an effective therapeutic modality for a large number of irreversible acute and chronic liver diseases. The results of liver transplantation have improved due to advances in operative technique, better understanding of the course and prognosis of several hver diseases and more effective postoperative care. The overall 5-year survival rate after liver transplantation for chronic Iiver disease has grown up to 70 - 85% and for acute liver failure up to 50 - 70%. The most common indication is end-stage chronic liver disease which accounts for 70% of liver transplantations. Among patients who have cirrhosis, chronic viral hepatitis and alcoholic liver disease are more frequent indications than they were a decade ago. In order to prolong life and to improve the quality of life, it is essential to define optimal patient selection and the ideal timing of transplantation during the course of advanced liver disease. Despite remarkable progress in Iiver transplantation, allograft rejection, infections and biliary complications remain a major cause of morbidity and mortality in liver transplant patients. Innovative immunosupressive therapies to prevent rejection and to avoid long-term consequences of chronic immunosupression continue to be explored. The incidence of infections is generally higher in liver transplant patients than that after kidney or heart transplantation. Viral diseases such as cytomegalovirus infection and reccurent hepatitis are the most frequent post-transplant infective complications.
Descriptors     LIVER TRANSPLANTATION
TISSUE DONORS
LIVER FAILURE
PREOPERATIVE CARE
IMMUNOSUPPRESSIVE AGENTS
POSTOPERATIVE COMPLICATIONS
GRAFT REJECTION
INFECTION