Author/Editor		Keber, Irena
Title		Smernice za zdravljenje dislipidemij
Translated title		Guidelines for dyslipidemia treatment
Type		članek
Source		Farm Vestn
Vol. and No.		Letnik 54, št. Poseb št
Publication year		2003
Volume		str. 119-22
Language		slo
Abstract		Dyslipidemias are among the major risk factors for atherosclerosis. The lowering of blood total and LDL cholesterol levels is the important preventive measure of atherosclerotic cardiovascular diseases. Therapeutic target levels of total and LDL cholesterol are <5 mmol/I and <3 mmol/l, respectively. The therapy of dyslipidemias consists of nonpharmacologic measures (therapeutic diet changes, regular physical activity) and usage of hypolipemic drugs. The management of high blood cholesterol in primary prevention in healthy people depends on global coronary risk asssessment. In low risk subjects only norpharmacologic measures are used, while in high risk subjects with absolute 10-year global coronary risk more than 20%, hypolipemic drugs are added, if therapeutic life style changes fail to achieve the target LDL cholesterol level. In secondary prevention of patients with coronary and other atherosclerotic cardiovascular diseases who are at high risk for further cardiovascular events, the treatment with hypolipemic drugs are necessary in most cases. The most frequently used hypolipemic drugs are statins. These drugs efficiently lower the blood LDL cholesterol level and decrease the coronary morbidity and mortality and the incidence of ischemic stroke.
Summary		Dislipidemije sodijo med glavne dejavnike tveganja za aterosklerozo. Zniževanje holesterola, predvsem holesterola LDL, je eden od ključnih preventivnih ukrepov pri preprečevanju aterosklerotičnih srčnožilnih boleznih. Ciljne vrednosti, ki jih želimo doseči z zdravljenjem, so za celotni holesterol manj kot 5 mmol(1 in holesterol LDL manj kot 3 mmol/1. Dislipidemije zdravimo z nefarmakološkimi ukrepi (prehrana, redna telesna dejavnost) in hipolipemiki. Pri obravnavi zvečanega krvnega holesterola v primarni preventivi pri še zdravih osebah moramo oceniti absolutno celokupno koronarno tveganje, kar storimo s pomočjo tabel koronarne ogroženosti, tako da upoštevamo prisotnost in izraženost vseh glavnih dejavnikov tveganja. Pri malo ogroženih je glavni terapevtski ukrep zdrav način življenja, kadar pa je 10-letno absolutno koronarno tveganje večje kot 20%, dodamo ob neuspešnosti nefarmakoloških ukrepov še hipolipemična zdravila. V sekundarni preventivi pri bolnikih s koronamo ali drugo aterosklerotično srčnožilno boleznijo, ki so zelo ogroženi pred ponovnimi srčnožilnimi dogodki, moramo nujno doseči ciljne vrednosti in je zato pri večini bolnikov potrebno sočasno nefarmakološko in farmakološko zdravljenje. Med hipolipemiki največ uporabljamo statine, ki najbolj znižajo krvni holesterol in tudi zmanjšajo koronarno obolevnost in umrljivost ter pojav ishemične možganske kapi.
Descriptors		HYPERLIPIDEMIA CORONARY DISEASE CORONARY ARTERIOSCLEROSIS RISK FACTORS LIPOPROTEINS, LDL CHOLESTEROL HEALTH FOOD DIET, FAT-RESTRICTED ANTILIPEMIC AGENTS