Author/Editor		Turel, Iztok; Golobič, Amalija; Klavžar, Aleš; Pihlar, Boris; Buglyo, Peter; Tolis, Evangelos; Rehder, Dieter; Sepčić, Kristina
Title		Interactions of oxovanadium(IV) and the quinolone family member - ciprofloxacin
Type		članek
Source		J Inorg Biochem
Vol. and No.		Letnik 95
Publication year		2003
Volume		str. 199-207
Language		eng
Abstract		The interactions of quinolone ciprofloxacin (cfH) and oxovanadium(IV) were studied by various methods. Green crystals of a complex [VIVO(cf)2(H2O)] were isolated and the molecular connectivities established, although the crystal structure was not perfectly refined due to the instability of the crystals. Based on a plausible interpretation of the data sets, two cf anions bidentately coordinate to a vanadyl cation through carboxylate and carbonyl oxygen atoms; in addition, there is a water molecule in the coordination sphere. Solution techniques (cyclic voltammetry, electronic and electron paramagnetic resonance spectroscopy, potentiometric measurements) coufirmed the presence of various species in the solution, the composition of which strongly depends on the condifions in the system. The antibacterial activity of the complex against various microorganisms was tested and it was established that its activity is similar to that of free ciprofloxacin.
Descriptors		VANADIUM CIPROFLOXACIN DRUG INTERACTIONS CRYSTALLOGRAPHY, X-RAY ELECTRON SPIN RESONANCE SPECTROSCOPY POTENTIOMETRY BACTERIA