Author/Editor		Varga, Tomaž; Kreuh-Kuhta, Blanka; Vidovič, Dušanka
Title		Etiopatogeneza in klinična slika KOPB
Translated title		Etiopathogenesis and clinical features of COPD
Type		članek
Source		In: Krajnc I, Hojs R, Pahor A, et al, editors. Zbornik predavanj in praktikum 14. srečanje internistov in zdravnikov splošne medicine Iz prakse za prakso z mednarodno udeležbo; 2003 maj 16-17; Maribor. Maribor: Splošna bolnišnica Maribor,
Publication year		2003
Volume		str. 9-19
Language		slo
Abstract		Chronic obstructive pulmonary disease is among the leading causes of morbidity and mortality worlwide and results in an economic and social burden that is both substantial and increasing. Chronic obstructive pulmonary disease prevalence, morbidity and mortality vary appreciably across countries and across different groups within countries, but in general are directly related to the prevalence of tobacco smoking. Most epidemiological studies have found that chronic obstructive pulmonary disease prevalence, morbidity and mortality have increased over time and are higher in men than in women. Smoking or exposure to inhaled noxious particles and gases causes inflammation of the lungs that can lead to chronic obstructive pulmonary disease if the normal protective and repair mechanisms are overwhelmed or defective. The irreversible component of airflow limitation is primarily due to remodeling of the small airways. Parenchymal destruction (emphysema) also contributes, but play a smaller role. The clinical features of chronic obstructive pulmonary disease are usually straightforward and care should be taken to evaluate those features of the disease, which are not typical.
Descriptors		LUNG DISEASES, OBSTRUCTIVE PULMONARY EMPHYSEMA BRONCHITIS SMOKING ALPHA 1-ANTITRYPSIN RISK FACTORS VITAL CAPACITY FORCED EXPIRATORY VOLUME