Author/Editor		Krobot, R; Premužič, J; Bacak, I
Title		The effect of prophylactic intravenous low-dose dexamethasone on nausea and vomiting after laparoscopic cholecystectomy
Type		članek
Source		In: Zabavnik Z, editor. Book of lectures of the 16th anaesthesia symposium Alpe Adria; 2003 May 9-11; Maribor. Maribor: Splošna bolnišnica,
Publication year		2003
Volume		str. 121-5
Language		eng
Abstract		Background: Postoperative nausea and vomiting (PONV) is unpleasent and frequent adverse effect of laparoscopic surgery. Goal of study was to evaluate antiemetic efficacy of prophylactic low-dose dexamethasone in patients undergoing laparoscopic cholecystectomy. Methods: A total of 80 patients undergoing laparoscopic cholecystectomy were assigned to two groups (n=40). All patients received TIVA with propofol, fentanyl and rocuronium. After tracheal intubation, patients received either dexamethasone 4 mg (Group DEX) or saline 1 ml (Group C). Nausea, vomiting and the need for rescue antiemetic medications were evaluated during 0-4h (early PONV) and 4-24 h (late PONV) periods postoperatively. Results: Groups were comparable in demographic data and anaesthetic drug dosage. The incidences of early PONV (0-4 h) in Group DEX were 2% (nausea 0% and vomiting 2%) and in Group C 17% (nausea 10% and vomiting 7%), P=0.05. The incidences of late PONV (4-24 h) were 11% in dexamethasone group (nausea 5% and vomiting 12%) and in control group 40% (nausea 15 % and vomiting 25%), P=0.04. During the total observation period 0-24 h postoperatively,incidences of PONV were 20% in dexamethasone group (nausea 5% and vomiting 15%) and 45% in control group (nausea 15% and vomiting 30%), P=0.03. The proportions of patients who required antiemetic treatment during 24-h period were 2 % in Group DEX and 20% in Group C, P=0.03. No clinically important side effects related to the use of dexamethasone were found. Conclusion: Prophylactic intravenous administration of dexamethasone 4 mg reduces the incidence of PONV as well as the need for rescue antiemetic medications in patients undergoing laparoscopic cholecystectomy.
Descriptors		DEXAMETHASONE NAUSEA VOMITING CHOLECYSTECTOMY, LAPAROSCOPIC POSTOPERATIVE COMPLICATIONS