Author/Editor		Legan, M; Kocijančič, A; Preželj, J; Osredkar, J; Fisker, S
Title		GH-IGF-I axis in non-obese women with functional hyperandnrogenism
Type		članek
Source		J Endocrinol Invest
Vol. and No.		Letnik 25, št. 8
Publication year		2002
Volume		str. 691-5
Language		eng
Abstract		The study was conducted to assess the GH-IGF-I axis in non-obese women with functional hyperandrogenism (FH). Eighteen FH women aged 18-35 yr with a body weight within 20% of ideal body weight and 10 weight-matched controls were included in the study. Basal serum GH, GH-binding protein (GHBP), IGF-I, IGF-binding protein-3 (IGFBP-3) levels were determined as well as GH levels during GHRH stimulation. In addition, basal serum androgens [free T (FT), delta4 and DHEAS], insulin and glucose levels were determined. The group of non-obese patients with FH differed from controls in GHBP (1.21±0.37 vs 0.93±0.25 nmol/I; p<0.05) and androgen levels (FT: 8.0±3.2 vs 1.9±1.2 pmol/I, p<0.001; delta4: 10.5±3.2 vs 5.9±2.1 nmol/I, p<0.001; DHEAS: 9.3±3.0 vs 5.1±1.8 micromol/I, p<0.001). GH (r=0.365; p<0.05) and IGF-I (r=0.508, p<0.01) serum levels were significantly correlated to serum DHEAS levels in a combined group of patients and controls. Our results support the suggestion that the GH-IGF-I axis plays an important role in the evolution of hormonal and metabolic derangement in non-obese FH women.
Descriptors		SOMATOTROPIN HYPERANDROGENISM INSULIN-LIKE GROWTH FACTOR I INSULIN-LIKE GROWTH-FACTOR-BINDING PROTEINS SOMATOTROPIN-RELEASING HORMONE