| Author/Editor | Kovač, Damjan | |
| Title | Monoklonska protitelesa proti receptorjem CD25 pri transplantaciji ledvice | |
| Type | monografija | |
| Place | Ljubljana | |
| Publisher | Medicinska fakulteta | |
| Publication year | 2003 | |
| Volume | str. 72 | |
| Language | slo | |
| Abstract | Immunosuppressive treatment is essential for prevention of kidney graft rejection. Immunosuppression, which includes corticosteroids, cyclosporine and azathioprine, has many side effects, particularly in corticosteroid treatment. The introduction of cyclosporine has diminished the rate of acute graft rejections and increased short-term kidney graft survival. Because of cyclosporine nephrotoxicity, long-term graft survival has not increased as significantly. Contemporary immunosuppressive treatment introduces new drugs that have fewer side effects and effectively prevent acute graft rejections. Mycophenolate mofetil prevents acute graft rejections more effectively than azathioprine. Monoclonal antibodies (basiliximab) against CD25 receptors on T lymphocytes prevent the effect of interleukin-2 (which plays the central role in acute graft rejection) without important side effects. New immunosuppressive drugs could allow the reduction of dose or exchange of some immunosuppressive drug and consecutively the reduction of side effects as well as better graft and patient survival. We tried to prove the hypothesis that the introduction of a new immunosuppressive treatment, including basiliximab and mycophenolate mofetil, allows the reduction of methylprednisolone and cyclosporine dosages without increasing the acute graft rejection rate in the first year after transplantation, without deterioration of one-year graft survival and without increased rate of infections and malignancy. n the first study, which is clinical, prospective-retrospective, 144 patients were included. According to immunosuppressive treatment, patients were divided into groups A and B. Group A consisted of 72 patients (44 men, 28 women, age 41 ± 13 years) treated with methylprednisolone, cyclosporine and, at the beginning, azathioprine. (Abstract truncated at 2000 characters). | |
| Descriptors | KIDNEY TRANSPLANTATION IMMUNOSUPPRESSIVE AGENTS ANTIBODIES, MONOCLONAL RECEPTORS, INTERLEUKIN-2 METHYLPREDNISOLONE CYCLOSPORINE AZATHIOPRINE GRAFT REJECTION CREATININE BACTERIAL INFECTIONS VIRUS DISEASES |