Author/Editor		Pavelić, Jasminka
Title		Molekularno-genetska osnova patogeneze sepse
Type		članek
Source		In: Baklan Z, Reberšek-Gorišek J, Kotnik-Kervokljan B, editors. Zbornik predavanj in praktikum Bedjaničev simpozij z mednarodno udeležbo o temi Sepsa in septični šok; 2003 maj 31-31; Maribor. Maribor: Splošna bolnišnica Maribor,
Publication year		2003
Volume		str. 67-77
Language		cro
Abstract		An uncontrolled cascade of coagulation, fibrinolysis and inflammation characterizes sepsis. The pathogenesis of sepsis is closely related to that of classical inflammation; they both include variety of go and stop signals, and pro- and anti-inflammatory cytokines, respectively. The inappropriate balance between pro- and anti-inflammatory responses contributes to the disease progression and outcomes of patients with sepsis. Therefore, all genes that encode proteins involved in the transduction of inflammatory processes are the candidate genes for determination of the human genetic background that is responsible for interindividual differences in systemic inflammatory responses to injury. Although at the very beginning, understanding the genetic basis of sepsis might help to reveal the patients that have high risks of developing severe sepsis, but also to reveal the patients that might benefit more that others from anti-sepsis therapy.
Descriptors		SEPSIS TUMOR NECROSIS FACTOR CYTOKINES PROTEIN C SHOCK, SEPTIC LIPOPOLYSACCHARIDES ANTIGENS, CD14 MACROPHAGE MIGRATION-INHIBITORY FACTORS