Author/Editor		Bensadon, M; O'Quigley, J
Title		Integral evaluation for continual reassessment method
Type		članek
Source		Comput Methods Programs Biomed
Vol. and No.		Letnik 42, št. 4
Publication year		1994
Volume		str. 271-3
Language		eng
Abstract		In this paper we show how the exact analytical solutions to the numerical integrals required in the implementation of the continual reassessment method can be evaluated. The formulas have been given but, with increasing sample size, rapidly become unwieldy. We develop an algorithm which uses the numerical binary representation of the subset size and, in the process, enables us to easily identify those members of the subset needed in the integral evaluation. The complex combinatorial problem of selecting the set of all subsets with a particular characteristic is then greatly simplified. We describe the nature and type of all the variables and parameters used in a PASCAL procedure.
Descriptors		MATHEMATICAL COMPUTING ALGORITHMS