Author/Editor		Meglič-Matoh, Veruška
Title		Antihipertenzitivna zdravila v nosečnosti
Translated title		Antihypertensive drugs in pregnancy
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 42, št. Suppl 3
Publication year		2003
Volume		str. 11-5
Language		slo
Abstract		For the associated complications arterial hypertension in pregnancy is one of the major causes of maternal and neonatal morbidity and mortality. In case of failure of nonpharmacological interventions, antihypertensive therapy is prescribed. The choice of the antihyperterišive drug is based on the drug's efficacy and favourable benefit-risk ratio for the mother and the fetus. In everyday clinical practice we tend to prescribe a well tested drug, in use for years. Methyl dopa is the most tested drug disposing with the least adverse effects, still the drug of choice for chronic treatment of hypertension in pregnancy. Antihypertensive drugs belonging to other pharmacological groups are usually prescribed as the second choice. In emergency hypertensive čonditions hydralazine or parenteral labetalol are administered.
Summary		Arterijska hipertenzija v nosečnosti je s svojimi zapleti eden glavnih vzrokov za obolevanje in umrljivost mater in otrok. V primeru neuspeha nefarmakoloških ukrepov uvedemo antihipertenzivno zdravilo. Izbira antihipertenzivnega zdravila temelji na učinkovitosti zdravila z ugodnim razmerjem med koristnostjo za mater in tveganjem za plod. Navadno predpišemo starejše in bolj raziskano zdravilo. Metildopa je najbolj preizkušeno zdravilo z najmanj neželenimi učinki in je še vedno izbirno zdravilo za kronično zdravljenje hipertenzije v nosečnosti. Antihipertenzivna zdravila nekaterih drugih farmakoloških skupin uporabljamo predvsem kot drugo zdravilo. Pri nujnih hipertenzivnih stanjih uporabljamo hidralazin ali labetalol v parenteralni obliki.
Descriptors		HYPERTENSION ANTIHYPERTENSIVE AGENTS PRE-ECLAMPSIA ECLAMPSIA PREGNANCY