Author/Editor		Peternel, Polona; Ambrožič, Aleš
Title		Preprečevanje in zdravljenje nosečnostnih in žilnih zapletov pri nosečnicah z antifosfolipidnim sindromom
Translated title		Prevention and treatment of obstetric and vascular complications in pregnant women with antiphospholipid syndrome
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 42, št. Suppl 3
Publication year		2003
Volume		str. 39-46
Language		slo
Abstract		Pregnant women with antiphospholipid syndrome (APS) have increased risk for venous or arterial thrombosis and obstetric complications threatening mother and fetus. The main cause of maternal mortality in western countries is venous thrombosis complicated with pulmonary embolism. Treatment of vascular complications in pregnancy differs from treatment in other patients. The live birth rate in non-treated pregnant women with APS is only 10 to 20%, however it rises up to 80% in treated pregnancies. Subcutaneous low-molecular-weight heparin and low dose aspirin is current standard therapy for management of thrombosis and prevention of obstetric complications in pregnant women with APS. Recommendatians for prevention and treatment of obstetric and vascular complications in pregnant women with APS do not meet criteria for the evidence-based medicine, in contrary, the recommendations mostly follow clinical experiences and retrospective studies.
Summary		Antifosfolipidni sindrom (APS) ogroža nosečnost s povečanim tveganjem za nastanek venske ali arterijske tromboze in z nosečnostnimi zapleti, ki ogrožajo mater in plod. Glavni vzrok maternalne smrtnosti v zahodnem svetu je venska tromboza s svojim zapletom pljučno embolijo. Zdravljenje žilnih zapletov v nosečnosti se razlikuje od zdravljenja v drugih obdobjih življenja. Delež živorojenih otrok pri nezdravljenih materah z APS je le 10-20 %. S preprečevanjem nosečnostnih zapletov pri materah z APS naraste delež živorojenih otrok na 80 %. Glavni zdravili, ki ju v navedenih primerih uporabljamo pri nosečnicah, sta aspirin in nizkomolekularni heparin. Priporočila za preprecevanje in zdravljenje nosečnostnih in žilnih zapletav pri ženskah z APS ne izpolnjujejo kriterijev, katerim mora zadostiti z izsledki podprta medicina, pač pa slone pretežno na kliničnih izkušnjah in retrospektivnih raziskavah.
Descriptors		ANTIPHOSPHOLIPID SYNDROME THROMBOSIS ANTICOAGULANTS HEPARIN COUMARINS PREGNANCY ASPIRIN THROMBOPHLEBITIS PREGNANCY