Author/Editor | Avčin, Tadej; Cerar-Kornhauser, Lilijana; Novak-Antolič, Živa | |
Title | Strokovna izhodišča za celostno obravnavo otrok, rojenih materam s sistemskimi vezivnotkivnimi boleznimi | |
Translated title | Expert proposition for management of children born to mothers with systemic connective tissue diseases | |
Type | članek | |
Source | Med Razgl | |
Vol. and No. | Letnik 42, št. Suppl 3 | |
Publication year | 2003 | |
Volume | str. 95-8 | |
Language | slo | |
Abstract | Systemic connective tissue diseases occur most commonly in women' of childbearing age. Transplacental transfer of IgG autoantibodies has been frequently demonstrated in a number of these disorders with demonstrable ill effects of offspring of affected mothers. The time course of clinical symptomatology often parallels the presumed half-life of IgG immunoglobulins. In this review the authors discuss the clinical manifestations of different neonatal autoimmune syndromes and present a proposal for the management and long term follow up of children born to mothers with systemic connective tissue diseases in Slovenia. | |
Summary | Sistemske vezivnotkivne bolezni se pogosto pojavljajo pri ženskah v rodni dobi. Ena izmed značilnosti teh bolezni je prisotnost avtoprotiteles, ki lahko med nosečnostjo prehajajo preko posteljice v plodov krvni obtok. Nekatera avtoprotitelesa, ki imajo neposredno patogenetsko vlogo, lahko pri transplacentarnem prenosu povzročijo značilne okvare pri plodu. Vrednost transplacentarno prenesenih protiteles in z njimi povezana klinična simptomatika pri otroku običajno izzvenijo v 6-12 mesecih. V prispevku predstavljamo predlog za celostno obravnavo otrok, rojenih materam s sistemskimi vezivnotkivnimi boleznimi v Sloveniji. | |
Descriptors | LUPUS ERYTHEMATOSUS, SYSTEMIC INFANT, NEWBORN, DISEASES INFANT, NEWBORN |