Author/Editor		Orel, Rok
Title		Vloga kislega gastroezofagealnega refluksa in duodenogastroezofagealnega refluksa v patogenezi refluksnega ezofagitisa pri otrocih in mladostnikih
Translated title		Role of acid gastroesophageal reflux and duodenogastroesophageal reflux in the pathogenesis of reflux esophagitis in children and adolescents
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		2003
Volume		str. 103
Language		slo
Abstract		Gastroesophageal reflux disease (GERD) is common in children and adolescents. Most cases of reflux esophagitis in children, especially very young children, are mild. The exception is children with predisposing factors such as neurological deficit, cystic fibrosis or operated anatomic anomalies of the foregut, and perhaps those with a strong genetic predisposition. Severe reflux esophagitis with complications such as esophageal stenosis and Barrett's esophagus can develop in these children. Previous studies have shown that the prognosis of children with untreated or inadequately treated severe reflux esophagitis is poor. We do not know the long-term consequences, even in adulthood, for undiagnosed and therefore untreated milder forms of childhood reflux esophagitis. The reflux of acid gastric juice, containing hydrochloric acid and pepsin, into the esophagus (acid GER) is a well-known causative factor of GERD. However, some cases of reflux esophagitis cannot be explained by the harmful action of acid GER alone. Both basic research and clinical studies in adult GERD patients have shown that duodenogastroesophageal reflux (DGER), containing bile and pancreatic enzymes, could also be an important factor in the pathogenesis of reflux esophagitis. DGER in children has not yet been studied. Therefore, its role, alone and together with acid GER, in the pathogenesis of reflux esophagitis in children is unknown. Given the results of the studies in adult patients, we decided to investigate this issue in children and adolescents. Aims The aims of our study were: 1. To explain the role of DGER, alone and in combination with acid GER, in the development of reflux esophagitis in children and adolescents by comparison of the results of the three groups of patients: without esophagitis, with mild or moderate esophagitis and with severe esophagitis. (Abstract truncated at 2000 characters).
Descriptors		GASTROESOPHAGEAL REFLUX DUODENOGASTRIC REFLUX ESOPHAGITIS, PEPTIC CHILD ADOLESCENCE DUODENOSCOPY ESOPHAGOSCOPY GASTROSCOPY BIOPSY HYDROGEN-ION CONCENTRATION ESOPHAGUS BILIRUBIN