| Author/Editor | Parežnik, Roman | |
| Title | Vpliv pojemanja učinka morfija na porabo kisika celega telesa pri nezapletenem akutnem miokardnem infarktu | |
| Type | monografija | |
| Place | Ljubljana | |
| Publisher | Medicinska fakulteta | |
| Publication year | 2003 | |
| Volume | str. 36 | |
| Language | slo | |
| Abstract | Background. In acute myocardial infarction (AMI) the metabolic rate is increased by pain, fear, neuroendocritte, and inflammatory response of the organism. Using indirect calorimetry increased oxygen consumption (VO2) was documented in uncomplicated AMI. In critically ill patients previously increased VO2 was temporary decreased by analgesic and sedative effects of morphine. After intravenous application of morphine its effect lasts 4-S hours. At time when the amount of myocardial necrosis is not definitive, increase of VO2 may be detrimental. The aim of our study was to determine whether the VO2 increases after cessation of morphine effect. Patients. Consecutive patients with uncomplicated AMI who received at least 0.1 mg morphine per kg of body weight less than an hour before admission were included in a prospective observational study. Methods. VO2 was measured using indirect calorimetry (gas exchange method). Measurements were performed 1-3 hours after admission (t0), 6 hours after the first measurement (t1), and 12 hours after the first measurement (t2). VO2-index (VO2-I =VO2/body surface area) was then calculated. The statistical analysis for paired data was performed to compare VO2-I at time t0 and t2 to VO2-I at time t0. The p value of less than 0.05 was considered statistically significant. Results. Twenty-seven patients were included. Mean VO2-I at time t0 was 155 +- 22 ml/min/m2, at time t1 was 166 +- 25 ml/min/m2 and at time t2 was 164 +- 25 ml/min/m2. From time t0 to time t1 V02I increased by 11 +- 18 ml/min/m2 (7%) (p= 0.006) and from time t0 to time t2 VO2 increased by 9 +- 19 ml/min/m2 (6%) (p=0.025). (Abstract truncated at 2000 characters). | |
| Descriptors | MYOCARDIAL INFARCTION MORPHINE OXYGEN CONSUMPTION CALORIMETRY, INDIRECT BODY TEMPERATURE PROSPECTIVE STUDIES |