Author/Editor		Radan, Ivan; Urbančič-Rovan, Vilma; Možina, Martin; Bručan, Andrej
Title		Serotoninski sindrom - prikaz primera
Translated title		Serotonin syndrome - case report
Type		članek
Source		In: Bručan A, Gričar M, Vajd R, editors. Urgentna medicina: izbrana poglavja. Zbornik 10. mednarodni simpozij o urgentni medicini; 2003 jun 11-14; Portorož. Ljubljana: Slovensko združenje za urgentno medicino,
Publication year		2003
Volume		str. 231-5
Language		slo
Abstract		The article describes a patient with clinical features of serotonine syndrome. A 35-yr-old woman was admitted following deliberate intoxication with tramadole, moclobemide (a monoaminooksigenase inhibitor), paroxetine (a selective serotonine reuptake inhibitor) and benzodiazepines. Upon admission she was unconscious, hyperthermic, diaphoretic with pronounced muscle rigidity. Toxicological analyses revealed the presenee of tramadol moclobemide and also paroxiten and zolpidem in smaller concentrations. After exclusion of other possible causes; serotonine syndrome was considered. Treatment was symptomatic with mechanical ventilation, sedation and neuromuscular block. The patient recovered spontaneously 24 hr later. Serotonine syndrome is characterized by varying degrees of cognitive, autonomic, and neuromuscular dysfunction and can only be triggered by drug therapy that increases central nervous system serotonin neurotransmission.
Descriptors		SUICIDE, ATTEMPTED SEROTONIN UPTAKE INHIBITORS MONOAMINE OXIDASE INHIBITORS BENZODIAZEPINES ADULT