Author/Editor		Soumarova, Renata; Horova, Hana; Šeneklova, Zuzana; Horova, Ivana; Budikova, Marie
Title		Prognostic outcome of local recurrence in breast cancer after conserving surgery and mastectomy
Translated title		Prognostična vrednost lokalne ponovitve bolezni pri raku dojke po ohranitveni kirurgiji in mastektomiji
Type		članek
Source		Radiol Oncol
Vol. and No.		Letnik 37, št. 2
Publication year		2003
Volume		str. 79-88
Language		eng
Abstract		Background. In our retrospective study we analysed local recurrences in breast cancer patients treated with conserving surgery (CS) followed by adjuvant radiotherapy (RT) or mastectomy (ME) with or without radiotherapy. We analysed the impact of local recurrence on overall survival. Patients and methods. Between 1980-1995, 306 patients underwent conserving surgery and 1,193 patients were done mastectomy in Masaryk Memorial Cancer Institute. The patients lost to follow-up were excluded. After all, we analysed 236 patients who underwent conserving surgery (Group A), and 1,121 who underwent mastectomy (Group B). All patients with CS received adjuvant RT of the breast with or without regional lymph nodes. In 982 patients (87,6%) with ME, we performed RT of the chest wall or without regional lymph nodes. Median age at the time of diagnosis was 48.3 years in Group A and 52.1 years in Group B. In Group A, 149 patients (63.1%) had T1 tumour, 86 (36.4%) T2 and 1(0.5%)T3. In 24.2% of patients, axillary node involvement was observed. In Group B, 316 patients (30.4%) had T1 tumour. 607 (58.3%) T2, 76 (7.3%) T3, 33 (3.2%) T4 and 9 (0.9%) TX. In 46.2% of these patients, we found axillary node involvement. Invasive ductal carcinoma was histologically proved in 67.4% in Group A and 84% in Group B. Systemic treatment was given to 133 patients (56.4%) from Group A and to 857 patients (76.4%) from Group B. Results. Median follow-up was 100.5 months in Group A and 121 months in Group B. In Group A, we registered 22 (9.3%) local recurrences, 5-year local control was 96.2% and median time to local recurrence was 50 months. In Group B, we registered 65 (5.8%) local recurrences; 5-year local control was 96.6%. Five-year local control in patients with T1, T2 tumours was 97.2%. In patients with adjuvant RT median time to local recurrence was 48.5 months, and in patients without adjuvant RT 51 months. (Abstract truncated at 2000 characters).
Summary		Izhodišča. V retrospektivni študiji smo analizirali lokalne ponovitve bolezni pri bolnicah z rakom dojke. Bolnice so bile zdravljenje z ohranitveno kirurgijo (CS), ki ji je sledila adjuvantna radioterapija (RT ali pa so bile zdravljenje z mastektomijo (ME) in nekatere od njih tudi z RT. Ugotavljali smo vpliv lokalne ponovitve bolezni na preživetje. Bolniki in metode. Med leti 1980-1995 smo v naši ustanovi zdravili 306 bolnic z ohranitveno kirurgijo in 1193 bolnic z mastektomijo. Izključili smo bolnice, pri katerih nismo uspeli slediti poteka bolezni. Tako smo analizirali 236 bolnic po CS (skupina A) in 1121 bolnic po ME (skupina B). Vsem bolnicam s CS smo obsevali operirano dojko, nekaterim pa tudi regionalne limfne bezgavke. Pri bolnicah z ME pa smo le pri 982 (87,6%) obsevali dojko in nekaterim od njih tudi regionalne bezgavke. Srednja starost v času diagnoze je bila 48,3 let v skupini A in 52,1 let v skupini B. V skupini A je imelo 149 bolnic (63,1%) tumor T1, 86 (36,4%) T2 in 1 (0,5%) T3. Pri 24,2% bolnic se je rak razširil v pazdušne bezgavke. V skupini B je imelo 316 (30,4%) bolnic tumor T1, 607 (58,3%) T2, 76 (7,3%) T3, 33 (3,2%) T4 in 9 (0,9%) TX. Pri 46,2% bolnic se je rak razširil v pazdušne bezgavke. Invazivni duktalni karcinom je bil histološko potrjen pri 67,4% bolnic v skupini A in 84% v skupini B. Sistemsko smo zdravili 133 (56,4%) bolnic iz skupini A in 857 (76,4%) bolnic iz skupine B. (Izvleček skrajšan na 2000 znakov)
Descriptors		BREAST NEOPLASMS MASTECTOMY NEOPLASM RECURRENCE, LOCAL RADIOTHERAPY, ADJUVANT PROGNOSIS SURVIVAL ANALYSIS NEOPLASM STAGING RETROSPECTIVE STUDIES