Author/Editor		Bitensky, Mark W; Yoshida, Tatsuro; Frank, Michael G; Gabel, Christopher V; Derganc, Jure
Title		Cellular diagnostic arrays, methods of using and processing for producing same
Type		monografija
Publisher		United states patent application
Publication year		2007
Volume		str. 14
Language		eng
Abstract		A cellular diagnostic array has been developed that provides accurate and reproducible measurements of the physical parameters of individual cells en masse, including cell membrane surface area, cell volume, and excess membrane. Three differing patterns are employed. In the first design, a gradient array having rectangular shaped channels is used to capture cells and readily show the ratio of volume to surface area for the captured cell. The second silicone rubber array provided by the present invention employs an array of wedge shaped pipettes, each of which captures an individual cell. The position of the cell within a wedge is enough to rapidly determine the cell's actual surface area and volume. A third type of cellular diagnostic array according to the present invention employs an array of channels designed to deform a cell to study how well the cell responds to repeated deformations.
Descriptors		CELL MEMBRANE CELL SIZE CELL MEMBRANE PERMEABILITY