Author/Editor		Pretnar, Gorazd; Steindl, Franz; Meager, Anthony; Thorpe, Robin; Borth, Nicole; Schmatz, Christine; Metzger, Rainer; Katinger, Herman WD; Ferlan, Igor
Title		Interferon alpha primes early proliferative response of bone marrow cells in vivo
Type		članek
Source		Cytokine
Vol. and No.		Letnik 10, št. 3
Publication year		1998
Volume		str. 185-91
Abstract		Using colony-forming assays, a number of previous studies established that interferon alpha (IFN-alpha) could cause bone marrow cell (BMC) suppression. In this study, the suppressive effect of IFN-alpha is however shown to be time-dependent, occurring only 7-8 days after transfer of BMC obtained from IFN-alpha-treated mice to growth factor-containing culture medium. In contrast, in the interval before suppression is observed, BMC obtained from IFN-alpha-treated mice initially proliferated more rapidly than BMC from placebo-treated mice. These findings suggest that IFN-alpha acts in vivo to prime the proliferative responses of BMC, a hitherto unexpected action which may have clinical relevance.
Descriptors		INTERFERON TYPE I BONE MARROW MICE, INBRED C57BL MACROPHAGE COLONY-STIMULATING FACTOR CELL DIVISION CELLS, CULTURED GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR