Author/Editor		Gračner, Tomaž
Title		Mjerenje brzine krvnog protoka u oku i orbiti pomoću obojenog Dopplera u dijabetičkoj retinopatiji
Translated title		Ocular blood flow velocity determined by color Doppler imaging in diabetic retinopathy
Type		monografija
Place		Zagreb
Publisher		Sveučilište u Zagrebu, Medicinski fakultet
Publication year		2003
Language		cro
Abstract		Background Diabetic retinopathy (DR) is the most common ocular complication of diabetes mellitus. In the developed world it still represents the main cause of blindness at an age between 20 and 74 years. Changes in circulation and consequently hemodynamic changes in the eye and orbit, which can be evaluated by color Doppler imaging (CDI), play the central role in the pathogenesis of DR. CDI is a non-invasive ultrasonic method which combines conventional B-mode image of tissue structure, color-coded blood flow information and measurements of blood flow velocity. The aim of this investigation was to establish whether CDI can serve to determine changes of blood flow velocity in the ophthalmic artery (OA), central retinal artery (CRA) and posterior ciliary artery (PCA) in DR and to compare the results with those in healthy control subjects. We also investigated whether the changes of blood flow velocity in the OA, CRA and PCA are significant with consideration to the different stages of DR progression. Patients and Methods In this investigation we included 44 eyes of 44 diabetic patients with different stages of DR forming the "DR" group and 22 eyes of 22 healthy age- and sex-matched subjects forming the control "ZD" group: With CDI we measured the peak systolic velocity (PSV, cm/s) and end diastolic velocity (EDV, cm/s) of blood flow in the OA, CRA and PCA. The resistance index (RI) of each vessel was then calculated. Statistical analysis comparing the results of group "DR" with group "ZD" was carried out. To find whether the changes of blood flow velocity in the OA, CRA amd PCA are significant considering the differentr stages of DR progression, we divided group "DR" in group "NPDR" (11 eyes with mild and 11 eyes with moderate nonproliferative DR) and group "PPDR/PDR" (19 eyes with preproliferative and 3 eyes with proliferative DR). (Abstract truncated at 2000 characters).
Descriptors		DIABETIC RETINOPATHY OPHTHALMIC ARTERY RETINAL ARTERY BLOOD FLOW VELOCITY ULTRASONOGRAPHY, DOPPLER, COLOR