Author/Editor		Nagai, Kensuke; Appelbaum, Peter C; Davies, Todd A; Kelly, Linda M; Hoellman, Dianne B; Tambić-Andrašević, Arjana; Drukalska, Liga; Hryniewicz, Waleria; Jacobs, Michael R; Kolman, Jana
Title		Susceptibility to telithromycin in 1,011 Streptococcus pyogenes isolates from 10 central and eastern European countries
Type		članek
Source		Antimicrob Agents Chemother
Vol. and No.		Letnik 46, št. 2
Publication year		2002
Volume		str. 546-9
Language		eng
Abstract		Among 1,011 recently isolated Streptococcus pyogenes isolates from 10 Central and Eastern European centers, the MICs at which 50% of isolates are inhibited (MIC50s) and the MIC90s were as follows: for telithromycin, 0.03 and 0.06 micro g/ml, respectively; for erythromycin, azithromycin, and clarithromycin, 0.06 to 0.125 and 1 to 8 micro g/ml, respectively; and for clindamycin, 0.125 and 0.125 micro g/ml, respectively. Erythromycin resistance occurred in 12.3% of strains. Erm(A) [subclass erm(TR)] was most commonly encountered (60.5%), followed by mef(A) (23.4%) and erm(B) (14.5%). At <0.5 micro g/ml, telithromycin was active against 98.5% of the strains tested.
Descriptors		ANTIBIOTICS, MACROLIDE STREPTOCOCCUS PYOGENES AZITHROMYCIN DRUG RESISTANCE, MICROBIAL ERYTHROMYCIN EUROPE, EASTERN GENES, BACTERIAL MICROBIAL SENSITIVITY TESTS