Author/Editor		Hedberg, Maria; Nord, Carl Erik; Kolman, Jana
Title		Antimicrobial susceptibility of Bacteroides fragilis group isolates in Europe
Type		članek
Source		Clin Microbiol Infect
Vol. and No.		Letnik 9, št. 6
Publication year		2003
Volume		str. 475-88
Language		eng
Abstract		Objective To evaluate the activity of old and newer antianaerobic drugs against clinical isolates of Bacteroides fragilis group strains from different parts of Europe. Methods Bacteroides fragilis group isolates from 37 laboratories in 19 countries were biochemically characterized. The MICs of seven antimicrobial agents were determined by the agar dilution method as recommended by the NCCLS. Production of betalactamase was detected by nitrocefin. Results There were 1284 B. fragilis group isolates included in the study. Abdominal infections and wounds were the most common sources of isolation and B. fragilis was the dominating species. Ninety-nine percent of the strains were resistant to ampicillin (breakpoint 2 mg/L), 6% to cefoxitin (64 mg/L), 15% to clindamycin (8 mg/L) and 9% to moxifloxacin (8 mg/L). Less than 1% were resistant to imipenem (16 mg/L), piperacillin-tazobactam (128 mg/L) and metronidazole (32 mg/L). Ninety-six percent of the isolates were beta-lactamase producers. Conclusions Antimicrobial resistance among the B. fragilis group is increasing.
Descriptors		BACTEROIDES FRAGILIS ANTIBIOTICS MICROBIAL SENSITIVITY TESTS EUROPE