Author/Editor     Globočnik-Petrovič, Mojca; Hawlina, Marko; Peterlin, Borut; Petrovič, Daniel
Title     BgIII gene polymorphism of the alpha2beta1 integrin gene is a risk factor for diabetic retinopathy in Caucasian with type 2 diabetes
Type     članek
Source     J Hum Genet
Vol. and No.     Letnik 48, št. 9
Publication year     2003
Volume     str. 457-60
Language     eng
Abstract     Platelets are thought to be involved in the pathogenesis of diabetic retinopathy. The BglII gene polymorphism of the alpha2beta1 integrin, which is a platelet collagen receptor, has been suggested as a genetic risk factor for diabetic retinopathy in Japanese subjects. The aim of this study was to look for a relationship between the BglII gene polymorphism of the alpha2beta1 integrin gene and the development of diabetic retinopathy in Caucasians with type 2 diabetes. Subjects with type 2 diabetes and diabetic retinopathy ( n=163) were compared with diabetic subjects without diabetic retinopathy ( n=95). A significantly higher frequency of the BglII (+/+) genotype of the gene polymorphism of the alpha2beta1 integrin gene was found in patients with diabetic retinopathy compared with patients without diabetic retinopathy (19.6% vs 7.4%; P=0.008). The present study demonstrates that the BglII (+/+) genotype of the gene polymorphism of the alpha2beta1 integrin gene is an independent risk factor (odds ratio: 2.4, 95% confidence interval 1.0-6.0; P<0.05) for diabetic retinopathy in Caucasians with type 2 diabetes.
Descriptors     DIABETES MELLITUS, NON-INSULIN-DEPENDENT
DIABETIC RETINOPATHY
POLYMORPHISM (GENETICS)
INTEGRINS
GENOTYPE
HYPERTENSION
LIPOPROTEINS, HDL CHOLESTEROL
LIPOPROTEINS, LDL CHOLESTEROL
TRIGLYCERIDES