Author/Editor		Korošec, Sara; Tomaževič, Tomaž; Verdenik, Ivan; Boc, Vinko; Premru-Sršen, Tanja; Virant-Klun, Irma; Valentinčič-Gruden, Brigita; Talan, Tanja
Title		Ali se dvojčki, rojeni po postopku zunajtelesne oploditve razlikujejo od dvojčkov rojenih po spontani zanositvi?
Translated title		Are the twins, born after an IVF-ET procedure any different than twins, born after spontaneous conception?
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 72, št. Suppl 2
Publication year		2003
Volume		str. II-79-84
Language		slo
Abstract		Background. Multiple pregnancy is in itself already a risk factor for the course and outcome of the pregnancy and birth. Its frequency in in-vitro fertilisation is approximately twenty fold in comparisori to natural conception which is also why it is one of the main problem areas of pregnancy and birth after an IVF-ETprocedure. The aim of our research is to determine whether the twins, born after an IVF-ETprocedure are any different than twins, born after spontaneous conception. Methods. The research was retrospective in nature. It included 1511 twin pregnancy patients who gave birth to twins between April 1987 and May 1995 and between January 1997 and December 1999. Our research group consisted of 255 mothers and 510 twins, born after an IVF-ETprocedure. The research was divided into a cohort and controlled study. In the cohort study the research group was compared to the entire Ljubljana cohort of 1256 mothers and 2512 twins resulting from spontaneous conception. In the controlled study 93 mothers and 186 twins from the research group were compared with 93 mothers and 186 newborns after spontaneous conception. In this group the mothers matched the research group in age, parity and birth year. The course of and complications during the pregnancy, and the course, complications and outcome of the birth as well as the characteristics of the newborns were compared. Results. Certain serious complications during the course of the pregnancy, including hypertension, gestation diabetes and threatened preterm labours, were no more frequent with the IVFgroup of mothers with twin pregnancy than with the control group. However more bleeding in the first trimester and less proteinuria were determined in comparison to the control group. (Abstract truncated at 2000 characters).
Summary		Izhodišča. Mnogoplodna nosečnost že sama po sebi predstavlja dejavnik tveganja za potek in izid nosečnosti in poroda. Njena pogostnost je pri zunajtelesni oploditvi približno dvajsetkrat večja kot pri naravni zanositvi, zato predstavlja enega večjih problemov nosečnosti in poroda po postopku IVF-ET. V raziskavi želimo ugotoviti, ali se dvojčki, spočeti po postopku IVF-ET razlikujejo od dvojčkov po spontani zanositvi. Metode. V retrospektivno raziskavo smo vključili 1511 mater z dvoplodno nosečnostjo in 3022 dvojčkov, ki so se rodili v obdobjih od aprila 1987 do maja 1995 in od januarja 1997 do decembra 1999. Raziskava je bila razdeljena na kohortno in kontrolirano primerjavo. V kohortni primerjavi smo primerjali preiskovano skupino 255 mater in 510 dvojčkov po postopku IVF-ET s celotno ljubljansko kohorto 1256 mater in 2512 dvojčkov po spontani zanositvi. Pri kontrolirani študiji pa smo primerjali preiskovano skupino 93 mater in 188 dvojčkov po postopku IVF-ET s 93 materami in 188 novorojenčki po spontani zanositvi, ob tem da smo matere izenačili po starosti, pariteti in letu poroda z materami preiskovane skupine. Primerjali smo potek in zaplete nosečnosti in poroda ter značilnosti novorojenčkov. Rezultati. V poteku nosečnosti nismo pri skupini mater IVFz dvoplodnim izidom nosečnosti ugotovili nič več zapletov (hipertenzivna obolenja v nosečnosti, gestacijski diabetes in grozeči prezgodnji porod), razen značilno več krvavitev v prvem trimesečju. Ugotovili smo značilno manj proteinurije kot v kontrolnih skupinah. V poteku in izidu poroda smo v skupini NF v primerjavi s kontrolnima skupinama ugotovili več prezgodnjih porodov (62,3-68,8% v primerjavi z 51,4-50,5%), 6 do 7 dni nižjo gestacijo in temu primerno težo ter trikrat več elektivnih in nujnih carskih rezov, kar je statistično značilno. Zaključki. Mnogoplodne nosečnosti so same po sebi zaplet postopka IVF. (Izvleček skrajšan na 2000 znakov).
Descriptors		FERTILIZATION IN VITRO PREGNANCY, MULTIPLE PREGNANCY INFANT, NEWBORN BIRTH WEIGHT APGAR SCORE