Author/Editor		Tomaževič, Tomaž; Virant-Klun, Irma; Valentinčič-Gruden, Brigita; Meden-Vrtovec, Helena; Vlaisavljević, Veljko; Kovačič, Borut; Reš, Primož; Verdenik, Ivan
Title		Dvajset let postopka zunajtelesne oploditve in mnogoplodna nosečnost
Translated title		Multiple pregnancy in the twenty years of IVF/ET in Slovenia
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 72, št. Suppl 2
Publication year		2003
Volume		str. II-105-8
Language		slo
Abstract		Background. Slovene data on iatrogenic multiple pregnancy after IVF/ICSI procedures are presented. The influence of elective transfer of two high-quality embryos on the incidence of iatrogenic multiple pregnancy were evaluated. Methods. Retrospective analysis of the Slovene NF/ICSI data in the period 1983-2000. Results. In 17436 IVF/ICSI cycles 3068 pregnancies were achieved. Of the 2308 deliveries 369 (16%) were twins and 49 (2%) triplets. Of the 2827 newborns 738 (26%) were twins and 148 (5%) triplets. With elective transfer of two high quality embryos in 1999 and 2000 in two of the three Slovene centres for assisted reproduction, the pregnancy rate per transfer increased (32%), triplet deliveries decreased to 2/492 deliveries (0.4%) (p < 0.000), and twin deliveries remained unchanged T 11/492 deliveries (23%). Conclusions. After elective transfer of two high-quality embryos and cryopreservation of surplus high-quality embryos in two of the three Slovene centres in the years 1999 and 2000, the problem of iatrogenic triple and higher rate multiple pregnancies has been successfully resolved, but the twin delivery rate still remains too high. Only by elective transfer of a single high-quality embryo the high multiple pregnancy rate after IVF/ICSI procedures could be avoided.
Summary		Izhodišča. Mnogoplodna nosečnost je v primerjavi z enoplodno nosečnostjo povezana z večjim perinatalnim tveganjem. Prikazujemo slovenske podatke o jatrogeni mnogoplodnosti po postopkih zunajtelesne oploditve. Ocenjujemo vpliv prenosa dveh izbranih kakovostnih zarodkov na pogostnost jatrogene mnogoplodnosti. Metode. Retrospektivno smo analizirali slovenske podatke o 17436 ciklusih IVF/ET v obdobju 1984-2000. Rezultati. V 17436 ciklusih IVF/ET je bilo doseženih 3068 nosečnosti. Med 2308 porodi je bilo 369 (16%) porodov dvojčkov in 49 (2%) porodov trojčkov. Med novorojenci je bilo 26% dvojčkov in 5% trojčkou Po uvedbi prenosa dveh izbranih kakovostriih zarodkov v dveh slovenskih centrih za OBMP, je delež zanositve na prenos zarodka v letih 1999 in 2000 porasel (32 nosečnosti na 100 prenosov zarodkov v letu 2000), delež porodov dvojčkov je ostal visok T 11/492 porodov (23%), delež porodov trojčkov se je statistično pomembno (p < 0, 0000) znižal na 2/492 (0,4%) porodov. Zaključki. Potem ko smo v dveh centrih uvedli prenos dveh izbranih kakovostnih zarodkov in zamrzovanje preostalih kakovostnth zarodkov, smo v Sloveniji skoraj povsem odpravili vprašanje jatrogene tri- in več plodne nosečnosti, delež porodov dvojčkov pa je ostal še vedno zelo visok (23%). Visokemu deležu mnogoplodnih nosečnostih po postopkih zunajtelesne oploditve se bo možno povsem izogniti le s pomočjo prenosa enega samega zarodka.
Descriptors		FERTILIZATION IN VITRO PREGNANCY, MULTIPLE PREGNANCY PREGNANCY OUTCOME