Author/Editor		Virant-Klun, Irma; Tomaževič, Tomaž; Zorn, Branko; Bačer-Kermavner, Lili; Valentinčič-Gruden, Brigita; Kmecl, Jerneja; Ribič-Pucelj, Martina; Vogler, Andrej; Bokal-Vrtačnik, Eda; Drobnič, Sašo; Pinter, Bojana; Mivšek, Jožica; Meden-Vrtovec, Helena
Title		Možnosti za prenos enega zarodka v postopku zunajtelesne oploditve
Translated title		Possiblilties for a single embryo transfer in an in vitro fertilization programme
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 72, št. Suppl 2
Publication year		2003
Volume		str. II-113-6
Language		slo
Abstract		Background. Since in in vitro fertilization two embryos - blastocysts are routinely transferred, the twin pregnancy rates are higher than in the general population. The aim of our study was to evaluate the clinical results after elective single-blastocyst transfer. Methods. Retrospectively we analysed clinical results of 696 in vitro fertilization cycles. The cycles were divided into 37 cycles, in which an elective single blastocyst transfer was performed (group 1), and in 659 cycles, in which an elective double blastocyst transfer was performed (group 2). The pregnancy rates, twin pregnancy rates, and spontaneous abortion rates were compared between the two groups. Additionally we evaluated the effect of the method of in vitro fertilization (classical IVF and ICSI) and female age (< 38 years and > 38 years) on the clinical results after a single or double blastocyst transfer Results. After an elective single or double blastocyst transfer, there was no statistically significant difference in pregnancy rates (30% vs. 46%); after a single blastocyst transfer there were no twin pregnancies, whereas after a double blastocyst transfer the pregnancy rate was 18%. After a double blastocyst transfer, the method of in vitro fertilization did not affect the twin pregnancy rate, whereas in women younger than 38 years, the twin pregnancy rate was significantly higher than in women aged > 38 years (19% vs. 6%; p < 0.05). Conclusions. Clinical results obtained after an elective single and double blastocyst transfer are comparable. By the transfer of one blastocyst twin pregnancies are avoided. Elective single blastocyst transfer is recommended in women, younger than 38 years.
Summary		Izhodišča. Ker v postopku zunajtelesne oploditve vnašamo v maternico dva zarodka - blastocisti, je delež dvoplodnih nosečnosti večji kot v splošni populaciji. Namen naše raziskave je bil ugotoviti klinične rezultate po elektivnem prenosu ene same blastociste. Metode. Retrospektivno smo analizirali rezultate 696 postopkov zunajtelesne oploditve. Postopke smo razdelili v dve skupini: 37 postopkov, v katerih smo v maternico elektivno prenesli eno samo blastocisto (skupina 1), in 659 postopkov, v katerih smo v maternico elektivno prenesli dve blastocisti (skupina 2) Primerjali smo stopnjo zanositve, delež dvoplodnih nosečnosti in delež spontanih splavov. Ugotavljali smo vpliv metode zunajtelesne oploditve (klasični IVF in ICSI) in starosti ženske (< 38 let in > 38 let) na klinične rezultate po prenosu ene ali dveh blastocist. Rezultati. Po prenosu ene ali dveh blastocist se stopnji nosečnosti nista statistično pomembno razlikovali (30% vs. 46%); po prenosu ene blastociste ni bilo nobene dvoplodne nosečnosti, po prenosu dveh blastocist je bilo 18% dvoplodnih nosečnosti. Metoda zunajtelesne oploditve ni vplivala na delež dvoplodnih nosečnosti po prenosu dveh blastocist, medtem ko je bil delež dvoplodnih nosečnosti pri ženskah, mlajših od 38 let, statistično pomembno večji kotpri starejših ženskah (19% vs. 6%; p < 0, 05). Zaključki. Klinični rezultati po elektivnem prenosu ene ali dveh blastocist so zelo primerljivi. S prenosom ene blastociste se izognemo dvoplodni nosečnosti. Elektivni prenos ene same blastociste je priporočljiv predvsem pri ženskah, mlajših od 38 let.
Descriptors		FERTILIZATION IN VITRO EMBRYO TRANSFER PREGNANCY PREGNANCY, MULTIPLE PREGNANCY OUTCOME