Author/Editor		Zorn, Branko; Virant-Klun, Irma; Drobnič, Sašo; Tomaževič, Tomaž; Meden-Vrtovec, Helena
Title		Mnogoplodne nosečnosti po postopkih neposrednega vnosa semenčice v citoplazmo jajčne celice (ICSI)
Translated title		Multiple pregnancies after intracytoplasmic sperm injection (ICSI)
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 72, št. Suppl 2
Publication year		2003
Volume		str. II-125-7
Language		slo
Abstract		Background. Because of complicattons related to multiple pregnancies after in vitro fertilization this pathology represent a real problem. Intracytoplasmic sperm injection (ICSI) may lead to higher risk in developing monozygotic pregnancies. We sought to investigate whether the multiple pregnancies after ICSI differ of those consecutive to classical in vitro fertilization (IVF) and if counseling for transfering one or at most two embryos is efficient in preventing multiple pregnancies. Methods. We analyzed retrospectively data concerning the incidence of multiple pregnancies before and after the transfer of limited number of embryos. Results. In transfering two cleaving stage embryos (day 2) or blastocysts (day 5), when pregnancy rate is high, the incidence of multiple pregnancies is 25 and 17%. After transfer of one blastocyst the highest the pregnancy rate and the lowest the incidence of multiple pregnancies. Conclusions. The best way to avoid multiple pregnancies consist in transferring one or at most two embryos. The monozygotic twin pregnancy we observed was consecutive to the transfer of frozen-thawed blastocyst.
Summary		Izhodišča. Zaradi zapletov, ki jih spremljajo, predstavljajo mnogoplodne nosečnosti v postopkih zunajtelesne oploditve velik problem. Metoda neposrednega vnosa semenčice v citoplazmo jajčne celice (ICSI) lahko poveča tveganje za razvoj monozigotne nosečnosti. Želeli smo ugotoviti, ali se mnogoplodne nosečnosti v postopkih ICSI razlikujejo od tistih v postopkih klasične zunajtelesne oploditve (IVF) in, ali je prenos enega zarodka ali največ dveh zarodkov učinkovit pri preprečevanju mnogoplodne nosečnosti. Metode. Retrospektivno smo analizirali podatke o incidenci mnogoplodnih nosečnosti pred in po uvedbi prenosa omejenega števila zarodkov. Rezultati. Ob prenosu dveh manjceličnikov (drugi dan) ali blastocist (peti dan) in dobri stopnji zanositve je incidenca mnogoplodnih nosečnosti 25% oziroma 27%. Poprenosu ene blastociste je stopnja zanositve najvišja (32 S%) in incidenca mnogoplodne nosečnosti najnižja (0%). Zaključki. Najboljši način, da se izognemo mnogoplodnim nosečnostim, je prenos enega zarodka ali največ dveh zarodkov. Ena sama monozigotna dvoplodna nosečnost, ki smo jo ugotovili, je nastala po prenosu odmrznjene blastociste.
Descriptors		PREGNANCY, MULTIPLE FERTILIZATION IN VITRO SPERMATOZOA EMBRYO TRANSFER PREGNANCY OUTCOME PREGNANCY