Author/Editor		Župan, G; Simonić, A; Ðorđević, N
Title		Dihidroergotoksin i pasivno izbjegavanje kazne u štakora s oštećenom kolinergičkom inervacijom korteksa
Translated title		Dihydroergotoxine and the passive avoidance behaviour in rats with damaged cholinergic innervation of the neocortex
Type		članek
Source		Acta Fac Med Flumin
Vol. and No.		Letnik 16, št. 1-2
Publication year		1991
Volume		str. 7-12
Language		cro
Abstract		The paper is dealing with the influence of dihydroergotoxine on the passive avoidance behaviour in rats with bilateral electrolytic lesions of the nucleus basalis. The mentioned basal forebrain structure lesions result in deficit of the cognitive activities. Dihydroergotoxine administered intraperitoneally in doses of 4,9.10 power -9 mol.kg power -1 or 4,9.10 power -8 mol.kg power -1 improved passive avoidance in lesioned animals. In doses of 4,9.10 power -7 mol.kg power -1 or 4,9.10 power -6 mol.kg power -1 didn't change and in dose of 2,45.10 power -5 mol.kg power -1 impaired the avoidance ability in lesioned rats. The conclusion is that the effect of dihydroergotoxine is dose-dependent in this experimental model
Descriptors		BASAL GANGLIA DIHYDROERGOTOXINE AVOIDANCE LEARNING BEHAVIOR, ANIMAL NEURAL TRANSMISSION DOSE-RESPONSE RELATIONSHIP, DRUG RATS, INBRED STRAINS RATS